Now Entering the US Market · Accepting Distributor Inquiries

Daily Gum Defense.
Backed by Science.

PerioRex reduces gum inflammation in small dogs aged 3 and older — powered by a US-patented Propolis + Mangosteen complex developed by a Korean biotechnology firm, clinically studied across 4 peer-reviewed publications and recognized by Korea's Ministry of Food and Drug Safety in 2025.

Partner With Us → View the Science
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MFDS Recognized Korea Ministry of Food & Drug Safety
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4 Published Studies SCIE peer-reviewed journals
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US Patent No. US 10,022,412 B2
PerioRex Gum Defence for Dogs — small dogs smiling
60 Biscuits 8-week supply
Vet Formulated · GMP Certified Made in Korea
40+
Years of Research
4
Peer-Reviewed Studies
94
Human Clinical Trial Subjects
5
Patents Worldwide
2025
MFDS Certified

The Problem

Gum disease is the most common health condition in pets

Most oral care products address surface bacteria. PerioRex goes deeper — targeting the inflammatory cascade and bone loss that drives real periodontal disease.

80%
of dogs show signs of gum disease by age 3 It begins silently, long before owners notice any symptoms.
#1
Most diagnosed condition at veterinary visits Periodontal disease affects more pets than any other health issue.
$0
Daily supplements clinically validated for gum health Until PerioRex, no daily supplement had peer-reviewed evidence for pet gum health.
Stages of Pet Gum Disease
1
Healthy Gums No signs — ideal window for prevention
2
Early Gingivitis Plaque buildup, mild inflammation begins
3
Established Gingivitis Redness, tenderness, bad breath
4
Periodontal Disease Bone loss, tooth instability, systemic risk
PerioRex works daily at stages 1–3 to help prevent progression
PerioRex Gum Defence for Dogs packaging
US Patent No. US 10,022,412 B2 GMP Certified · Vet Formulated
🐕 Small Dogs · 3 Years & Older

PerioRex Gum Defence

A once-daily supplement that reduces gum inflammation and helps maintain jawbone density in small dogs aged 3 and older — from the inside out.

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Supports Healthy Gums

Propolis + Mangosteen complex targets inflammatory biomarkers linked to gum tissue breakdown.

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Reduces Gum Inflammation

Demonstrated reduction in PGE₂, IL-1β, MMP-8, and MMP-9 in randomized clinical trial — the core mechanism behind PerioRex.

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Supports Jawbone Health

Animal studies show up to 28.9% inhibition of alveolar bone loss under periodontal stress.

60 BiscuitsPer container
8 WeeksSupply duration
Once DailyChewable treat

Active Ingredients

Powered by natural antioxidants

The PMEC (Propolis-Mangosteen Extract Complex) is a proprietary blend invented by a Korean biotechnology firm and developed through extensive research at leading Korean dental and biotechnology institutions.

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Propolis Extract

A natural resin collected by bees, rich in polyphenols including Galangin. Used in whole form for maximum bioactive compound retention and anti-inflammatory activity.

Marker compoundGalangin
Primary functionAnti-inflammatory
Evidence levelSCIE Published · MFDS
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Mangosteen Rind Extract

Garcinia mangostana L. fruit rind — one of nature's richest sources of xanthones. α-Mangostin provides potent antioxidant and bone-protective properties.

Marker compoundα-Mangostin
Primary functionBone protection
Evidence levelUS Patent + SCIE + MFDS
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Zinc (as Zinc Oxide)

9.5 mg per biscuit (77% DV). Supports immune function and healthy tissue maintenance.

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Selenium

55 μg per biscuit (100% DV). Helps protect cells from oxidative damage.

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Manganese

3 mg per biscuit (130% DV). Supports bone formation and energy metabolism.

Clinical Evidence

The science behind every biscuit

Seven years of rigorous research — from in vitro cell studies to a double-blind randomized controlled trial — published across 4 SCIE-indexed peer-reviewed journals.

01
In Vitro Study · 2020
Anti-inflammatory and bone formation effects of Garcinia mangostana L. and propolis extracts in human gingival and osteoblast-like cells
↓ IL-6, IL-8, PGE₂ (inflammation) ↑ RUNX2, COL1A1, Osteocalcin (bone formation) ↑ ALP activity & bone mineralization
Food Science and Biotechnology (SCIE), 29(4):539–548 (2020)
02
Animal Study · 2019
Inhibition of inflammation and alveolar bone loss in ligature-induced periodontitis in rats — 3-week daily oral administration
↓ PGE₂, IL-8, iNOS, COX-1, COX-2 ↓ MMP-8 (gum tissue destruction marker) Alveolar bone loss inhibited
International Journal of Oral Biology (SCIE), 44(2):55–61 (2019)
03
Animal Study · 2021
Alveolar bone loss inhibition under high-inflammation conditions (20× LPS stress) — dose-response confirmed in rat periodontitis model
24.3% bone loss inhibition at standard dose 28.9% inhibition at double dose Effective under extreme inflammatory stress
Korean Journal of Dental Materials, 48(2):71–78 (2021)
04
Randomized Double-Blind Placebo-Controlled Trial · 2024
Clinical effect of Propolis + Mangosteen complex in subjects with gingivitis — 8-week RCT, n=94 adults, conducted at Ajou University & Seoul St. Mary's Hospital
↓ PGE₂, IL-1β (inflammation biomarkers) ↓ MMP-8, MMP-9 (tissue destruction markers) Double-blind · Placebo-controlled · 94 subjects
Nutrients (SCIE), 16(17):3000 (2024)
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Korea MFDS Functional Ingredient Recognition — March 25, 2025

Certificate No. 2025-13 · Issued by the Ministry of Food and Drug Safety, Republic of Korea. The PMEC complex is officially recognized as a functional ingredient with the approved health claim: "May help alleviate gum condition." Recognition followed full clinical dossier review including two independent human clinical trials conducted at major Korean university hospitals. This is the Korean equivalent of a GRAS or qualified health claim — the highest level of functional food ingredient recognition in Korea.

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United States Patent

US 10,022,412 B2

Composition for preventing/improving periodontal disease using mangosteen extract

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Korea — 3 Patents

10-17775613 · 10-1879398 · 10-1989971

Periodontal disease prevention, bone formation promotion, and root canal compositions

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Japan Patent

6387467

Composition for preventing/improving periodontal disease using mangosteen extract

Competitive Advantage

A category of one

No other pet oral care supplement combines clinical evidence, a US patent, and a government-recognized functional ingredient.

Feature

PerioRex

Typical Competitors

US Patent Protection
✓
✗
Government-Recognized Functional Ingredient (MFDS 2025)
✓
✗
Published Randomized Controlled Trial (Human)
✓ Nutrients 2024
✗
Peer-Reviewed Animal Studies (SCIE indexed)
✓ 3 studies
Rare
Targets Inflammation Biomarkers (not just bacteria)
✓
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Demonstrated Jawbone Protection
✓
✗
GMP Certified Manufacturing
✓
Varies
Once-Daily Chewable Biscuit (high owner compliance)
✓
Varies

Business Opportunity

We're building US distribution

PerioRex is entering the American market and selectively partnering with national distributors, e-commerce platforms, veterinary supply companies, and retail chains across all 50 states.

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E-Commerce Partners

Ideal for high-volume online retail with data-driven pet supplement audiences.

  • Chewy.com
  • Amazon Pet
  • PetFlow
  • DTC online platforms
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Retail Chains

Strategic placement in premium pet specialty and mass pet retail environments nationwide.

  • PetSmart
  • Petco
  • Pet Supplies Plus
  • Independent pet boutiques
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Veterinary Supply

Vet-recommended positioning backed by clinical evidence for professional endorsement.

  • Veterinary distributors
  • Animal hospital chains
  • Vet-exclusive channels
  • Dental specialist practices
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National Distributors

Full-line pet distribution partnerships for nationwide warehouse and logistics coverage.

  • Regional exclusivity available
  • Co-marketing support
  • Marketing materials provided
  • Sales team training support
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Private Label

License the patented PMEC formulation under your own brand with full IP documentation.

  • US Patent licensed
  • MFDS documentation included
  • Custom packaging available
  • Full scientific dossier
🤝

Strategic Brand Partners

Joint ventures, co-branding opportunities, and market expansion partnerships.

  • Pet insurance companies
  • Subscription box platforms
  • Telehealth vet platforms
  • Pet wellness brands

Ready to bring PerioRex to your customers?

We're accepting inquiries from qualified US partners. Product samples, sell sheets, and the full scientific dossier are available upon request.

Start a Conversation → info@periorex.com

Get in Touch

Let's talk partnership

Whether you're a national distributor, e-commerce buyer, or specialty retailer — we'd like to hear from you. We provide full scientific documentation, product samples, and co-marketing support to qualified partners.

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Business Development info@periorex.com
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Headquarters 25-11 Palpan-gil, Jongno-gu, Seoul, Republic of Korea
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Available on Request Product Brochure · Sell Sheet · Scientific Papers · Animal Study Summary · Clinical Evaluation · MFDS Certificate · Patent Information · Product Samples
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Manufacturer Medibio Lab Co., Ltd. — Korean Biotechnology Firm · GMP Certified · Seoul, Korea

Partnership Inquiry