Science That Helps Protect Gums and Alveolar Bone
Now Entering the US Market · Accepting Distributor Inquiries

Daily Gum Care.
Backed by Science.

PerioRex is a science-backed daily oral health supplement for dogs and cats powered by a US-patented government-approved ingredient complex — clinically studied across 4 peer-reviewed publications and recognized by Korea's Ministry of Food and Drug Safety in 2025.

Partner With Us → View the Science
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MFDS Recognized Korea Ministry of Food & Drug Safety
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4 Published Studies SCIE peer-reviewed journals
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US Patent No. US 10,022,412 B2
PerioRex Pet — daily dental support for small dogs and cats
60 Biscuits 8-week supply
Vet Formulated · GMP Certified Made in Korea
7+
Years of R&D
4
Peer-Reviewed Studies
94
Human Clinical Trial Subjects
5
Patents Worldwide
2025
MFDS Certified

The Problem

Gum disease is the most common health condition in pets

Most oral care products address surface bacteria. PerioRex goes deeper — targeting the inflammatory cascade and bone loss that drives real periodontal disease.

70%
of small dogs and cats show signs of periodontal disease by age 3 It begins silently, long before owners notice any symptoms.
#1
Most diagnosed condition at veterinary visits Periodontal disease affects more pets than any other health issue.
$0
Daily supplements clinically validated for gum health Peer-reviewed evidence for daily pet gum supplements has been rare — PerioRex is backed by 4 SCIE-indexed studies.
Stages of Pet Gum Disease
1
Healthy Gums No signs — ideal window for prevention
2
Early Gingivitis Plaque buildup, mild inflammation begins
3
Established Gingivitis Redness, tenderness, bad breath
4
Periodontal Disease Bone loss, tooth instability, systemic risk
PerioRex works daily at stages 1–3 to help prevent progression
PerioRex Gum Defense for Pets packaging
US Patent No. US 10,022,412 B2 GMP Certified · Vet Formulated
🐕 For Dogs  ·  🐈 For Cats

PerioRex Gum Defence

A once-daily biscuit that supports healthy gums, reduces gum inflammation, and helps maintain jawbone density — from the inside out.

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Supports Healthy Gums

Government-approved ingredient complex targets inflammatory biomarkers linked to gum tissue breakdown.

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Helps Reduce Gum Inflammation

Demonstrated reduction in PGE₂, IL-1β, MMP-8, and MMP-9 in randomized clinical trial.

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Supports Jawbone Health

Animal studies show up to 28.9% inhibition of alveolar bone loss under periodontal stress.

60 BiscuitsPer container
8 WeeksSupply duration
700 mgPer biscuit
Once DailyGiven as a treat

Active Ingredients

Powered by natural antioxidants

The PMEC is a proprietary government-approved ingredient complex developed over 7 years of research at leading Korean dental and biotechnology institutions.

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Active Complex A

A natural plant-derived extract standardized for consistent anti-inflammatory activity. Used in whole form for maximum bioactive compound retention.

Primary functionAnti-inflammatory
Evidence levelSCIE Published · MFDS
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Active Complex B

A concentrated plant-based extract standardized for potent antioxidant and bone-protective activity.

Primary functionBone protection
Evidence levelUS Patent + SCIE + MFDS

Clinical Evidence

The science behind every biscuit

Seven years of rigorous research — from in vitro cell studies to a double-blind randomized controlled trial — published across 4 SCIE-indexed peer-reviewed journals.

01
In Vitro Study · 2020
Anti-inflammatory and bone formation effects of the PMEC complex in human gingival and osteoblast-like cells
↓ IL-6, IL-8, PGE₂ (inflammation) ↑ RUNX2, COL1A1, Osteocalcin (bone formation) ↑ ALP activity & bone mineralization
Food Science and Biotechnology (SCIE), 29(4):539–548 (2020)
02
Animal Study · 2019
Inhibition of inflammation and alveolar bone loss in ligature-induced periodontitis in mice — 3-week daily oral administration
↓ PGE₂, IL-8, iNOS, COX-1, COX-2 ↓ MMP-8 (gum tissue destruction marker) Alveolar bone loss inhibited
International Journal of Oral Biology (SCIE), 44(2):55–61 (2019)
03
Animal Study · 2021
Alveolar bone loss inhibition under high-inflammation conditions (20× LPS stress) — dose-response confirmed in mouse periodontitis model
24.3% bone loss inhibition at standard dose 28.9% inhibition at double dose Effective under extreme inflammatory stress
Korean Journal of Dental Materials, 48(2):71–78 (2021)
04
Randomized Double-Blind Placebo-Controlled Trial · 2024
Clinical effect of the PMEC complex in subjects with gingivitis — 8-week RCT, n=94 adults, conducted at Ajou University & Seoul St. Mary's Hospital
↓ PGE₂, IL-1β (inflammation biomarkers) ↓ MMP-8, MMP-9 (tissue destruction markers) Double-blind · Placebo-controlled · 94 subjects
Nutrients (SCIE), 16(17):3000 (2024)
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Korea MFDS Functional Ingredient Recognition — March 25, 2025

Certificate No. 2025-13 · Issued by the Ministry of Food and Drug Safety, Republic of Korea. The PMEC complex is officially recognized as a functional ingredient with the approved health claim: "May help alleviate gum condition." Recognition followed full clinical dossier review including two independent human clinical trials conducted at major Korean university hospitals. This is a rigorous Korean government functional-ingredients recognition — the highest level of functional food ingredient recognition in Korea.

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United States Patent

US 10,022,412 B2

Composition for preventing/improving periodontal disease

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Korea — 3 Patents

10-17775613 · 10-1879398 · 10-1989971

Periodontal disease prevention, bone formation promotion, and root canal compositions

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Japan Patent

6387467

Composition for preventing/improving periodontal disease

DL

Mr. Daesung Lee

Co-CEO & Founder

Former Professor
College of Pharmacy
Seoul National University

The Team Behind PerioRex Pet

Decades of pharmaceutical research, channeled into a single mission

PerioRex Pet is developed by Medibio Lab Co., Ltd., a Korean R&D biotechnology company founded by Mr. Daesung Lee — former Professor at Seoul National University College of Pharmacy, Korea's most prestigious pharmaceutical institution.

Following seven years of intensive R&D, four peer-reviewed SCIE-indexed publications, two independent human clinical trials at major Korean university hospitals, and issued patents across the United States, Korea, and Japan, PerioRex Pet delivers the same patent-protected complex to companion animals. Commercial production is carried out by Biofarm, a GMP-certified manufacturing partner.

Competitive Advantage

A category of one

Few pet oral care supplements combine clinical evidence, a US patent, and a government-recognized functional ingredient.

Feature

PerioRex

Typical Competitors

US Patent Protection
✓
✗
Government-Recognized Functional Ingredient (MFDS 2025)
✓
✗
Published Randomized Controlled Trial (Human)
✓ Nutrients 2024
✗
Peer-Reviewed Animal Studies (SCIE indexed)
✓ 3 studies
Rare
Targets Inflammation Biomarkers (not just bacteria)
✓
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Demonstrated Jawbone Protection
✓
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GMP Certified Manufacturing
✓
Varies
Once-Daily Biscuit (high owner compliance)
✓
Varies

FAQ

Answers buyers and partners want

Common questions from distributors, retailers, and veterinary partners evaluating PerioRex Pet for their catalogs.

What the product is
Periodontal disease is the most common health condition diagnosed in dogs and cats — over 70% of dogs and cats show clinical signs by age 3. In the US, this represents a large, chronically underserved daily-supplement opportunity across pet retail, e-commerce, and veterinary channels.
Once-daily 700 mg biscuit, given as a treat. 60 biscuits per bottle — an 8-week supply per pet.
The government-approved ingredient complex targets the inflammatory biomarkers (PGE₂, IL-1β, MMP-8, MMP-9) that drive gum tissue breakdown and bone loss — not just surface bacteria.
In the human RCT the underlying complex was based on, statistically significant biomarker changes were observed after 8 weeks of daily use. Owner-observable improvements — breath, gum color — typically follow.
The formulation uses food-grade, plant-derived ingredients recognized by Korea's MFDS as a functional food ingredient. As with any supplement, we recommend consulting a veterinarian for pets on active medications.
A patented government-approved ingredient complex plus additional supporting nutrients at meaningful daily-value levels. Full ingredient dossier available under NDA.
Partnering with us
Developed by Medibio Lab Co., Ltd. (Korean R&D biotechnology) and manufactured by Biofarm in Seoul under GMP standards, with capacity to scale for national US retail programs.
Full scientific dossier, MFDS certificate, patent documentation, 4 peer-reviewed SCIE studies, product brochure, sell sheet, and clinical trial summaries — all available on request under NDA.
GMP-certified manufacturing, US Patent No. US 10,022,412 B2, three Korean patents, one Japanese patent, and Korea MFDS functional ingredient recognition (Certificate No. 2025-13, issued March 25, 2025).
Yes, for qualified national distributors and strategic partners. Terms are negotiated based on channel commitment, volume, and marketing investment.
Yes. Private-label partners commission PerioRex Pet under their own brand, with custom packaging, full regulatory support, and access to product documentation. Manufacturing remains with Biofarm.
Reach out via the partnership form below or email info@periorex.com. We'll follow up with samples, sell sheets, and a full dossier under NDA.

Business Opportunity

We're building US distribution

PerioRex is entering the American market and selectively partnering with national distributors, e-commerce platforms, veterinary supply companies, and retail chains across all 50 states.

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E-Commerce Partners

Ideal for high-volume online retail with data-driven pet supplement audiences.

  • Chewy.com
  • Amazon Pet
  • PetFlow
  • DTC online platforms
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Retail Chains

Strategic placement in premium pet specialty and mass pet retail environments nationwide.

  • PetSmart
  • Petco
  • Pet Supplies Plus
  • Independent pet boutiques
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Veterinary Supply

Vet-recommended positioning backed by clinical evidence for professional endorsement.

  • Veterinary distributors
  • Animal hospital chains
  • Vet-exclusive channels
  • Dental specialist practices
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National Distributors

Full-line pet distribution partnerships for nationwide warehouse and logistics coverage.

  • Regional exclusivity available
  • Co-marketing support
  • Marketing materials provided
  • Sales team training support
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Private Label

Distribute PerioRex Pet under your own brand with custom packaging and full regulatory support.

  • Custom packaging & branding
  • MFDS documentation included
  • Manufactured by Biofarm (GMP)
  • Full scientific dossier
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Strategic Brand Partners

Joint ventures, co-branding opportunities, and market expansion partnerships.

  • Pet insurance companies
  • Subscription box platforms
  • Telehealth vet platforms
  • Pet wellness brands

Ready to bring PerioRex to your customers?

We're accepting inquiries from qualified US partners. Product samples, sell sheets, and the full scientific dossier are available upon request.

Start a Conversation → info@periorex.com

Get in Touch

Let's talk partnership

Whether you're a national distributor, e-commerce buyer, or specialty retailer — we'd like to hear from you. We provide full scientific documentation, product samples, and co-marketing support to qualified partners.

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Business Development info@periorex.com
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Headquarters 25-11 Palpan-gil, Jongno-gu, Seoul, Republic of Korea
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Available on Request Product Brochure · Sell Sheet · Scientific Papers · Animal Study Summary · Clinical Evaluation · MFDS Certificate · Patent Information · Product Samples
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Manufacturer Developed by Medibio Lab Co., Ltd. (Korean R&D biotechnology, Seoul). Manufactured by Biofarm — GMP-certified · Est. 2011.

Partnership Inquiry